PT-2025-45583 · Openclinic · Openclinica Community Edition

Mikecole-Mg · Published 2025-11-09 · Updated 2025-12-02 · CVE-2025-12921

Positive Technologies (AI Summary)

CVSS v3.1

8.8

High

Base vector

AV:N/AC:L/PR:L/UI:N/S:U/C:H/I:H/A:H

Name of the Vulnerable Software and Affected Versions OpenClinica Community Edition versions up to 3.12.2/3.13

Description A flaw exists in OpenClinica Community Edition that allows for XML injection. This issue is related to the processing of the xml file argument within the /ImportCRFData?action=confirm endpoint of the CRF Data Import component. Successful exploitation could occur remotely. The details of the exploit have been publicly disclosed.

Recommendations Versions prior to 3.12.2/3.13 should be updated.

Exploit

Fix

Special Elements Injection

Weakness Enumeration

CWE-74

CWE-91

Related Identifiers

CVE-2025-12921

Affected Products

Openclinica Community Edition

References · 11

• 🔥 https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md#poc · Exploit
• 🔥 https://github.com/mikecole-mg/security_findings/blob/main/openclinica/openclinica-xxe.md · Exploit
• https://nvd.nist.gov/vuln/detail/CVE-2025-12921 · Security Note
• https://osv.dev/vulnerability/CVE-2025-12921 · Vendor Advisory
• https://t.me/CVEtracker/36878 · Telegram Post
• https://twitter.com/CVEnew/status/1987666305814593739 · Twitter Post
• https://vuldb.com/?id.331641 · Note
• https://t.me/cveNotify/142226 · Telegram Post
• https://twitter.com/dailycve/status/1995936644151869853 · Twitter Post
• https://vuldb.com/?ctiid.331641 · Note
• https://vuldb.com/?submit.680872 · Note